The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The search for new drugs has been greatly accelerated by the emergence of new viruses
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …

The development of technologies for the efficient synthesis of innovative antiviral
compounds remains an important challenge for modern biotechnology, especially in the …

Emerging and re-emerging viruses have been a challenge in public health in recent
decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved …

HIV/AIDS mortality has been decreasing over the last decade. While promising, this
decrease correlated directly with increased use of antiretroviral drugs. As a natural …

We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting
Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant …

A new simple, selective, rapid, precise reversed-phase high-performance liquid
chromatography method has been developed and validated for the estimation of …

Background and Purpose There is a need for effective anti‐COVID‐19 treatments, mainly for
individuals at risk of severe disease such as the elderly and the immunosuppressed. Drug …

Objective Rapid transmission and reproduction of RNA viruses prepare conducive
conditions to have a high rate of mutations in their genetic sequence. The viral mutations …

The concept of a mild mutagen was coined to describe a minor mutagenic activity exhibited
by some nucleoside analogues that potentiated their efficacy as antiretroviral agents. In the …