Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

A characteristic feature of the human airway epithelium is the presence of ciliated cells
bearing motile cilia, specialized cell surface projections containing axonemes composed of …

Although destructive airway disease is evident in young children with cystic fibrosis (CF),
little is known about the nature of the early CF lung environment triggering the disease. To …

Cystic fibrosis (CF) is a heritable, multiorgan disease that impacts all tissues that normally
express cystic fibrosis transmembrane conductance regulator (CFTR) protein. While the …

Cystic fibrosis (CF) is both the most common and most lethal genetic disease in the
Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane …

The mucosa of the gastrointestinal tract, eyes, nose, lungs, cervix and vagina is lined by
epithelium interspersed with mucus-secreting goblet cells, all of which contribute to their …

Question Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent
mucus in the lungs. While several hypotheses invoke a direct relationship with cystic fibrosis …

Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD),
are critical areas of medical research, as millions of people are affected worldwide. In fact …

Small molecular modulators of the cystic fibrosis transmembrane conductance regulator
protein are transforming the care of people with cystic fibrosis. Highly effective modulators …

The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …