Effect of GH/IGF‐1 on bone metabolism and osteoporsosis

V Locatelli, VE Bianchi - International journal of endocrinology, 2014 - Wiley Online Library
Background. Growth hormone (GH) and insulin‐like growth factor (IGF‐1) are fundamental
in skeletal growth during puberty and bone health throughout life. GH increases tissue …

[PDF][PDF] Francesco Giorgino

S Perrini, L Laviola, MC Carreira… - Journal of …, 2010 - researchgate.net
The widespread increase in life expectancy is accompanied by an increased prevalence of
features of physical frailty. Signs and symptoms may include sarcopenia and osteopenia …

Activation of the maternal immune system induces endocrine changes in the placenta via IL-6

EY Hsiao, PH Patterson - Brain, behavior, and immunity, 2011 - Elsevier
Activation of the maternal immune system in rodent models sets in motion a cascade of
molecular pathways that ultimately result in autism-and schizophrenia-related behaviors in …

Bone-to-brain: a round trip in the adaptation to mechanical stimuli

L Gerosa, G Lombardi - Frontiers in Physiology, 2021 - frontiersin.org
Besides the classical ones (support/protection, hematopoiesis, storage for calcium, and
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …

Role of insulinlike growth factor 1 in fetal development and in the early postnatal life of premature infants

A Hellström, D Ley, I Hansen-Pupp… - American journal of …, 2016 - thieme-connect.com
The neonatal period of very preterm infants is often characterized by a difficult adjustment to
extrauterine life, with an inadequate nutrient supply and insufficient levels of growth factors …

Revisiting the IGF-1R as a breast cancer target

RC Ekyalongo, D Yee - NPJ precision oncology, 2017 - nature.com
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and
multiple clinical trials examining insulin-like growth factor-1 receptor have been completed …

Crosstalk of brain and bone—clinical observations and their molecular bases

E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Anabaenopeptins and cyanopeptolins induce systemic toxicity effects in a model organism the nematode Caenorhabditis elegans

KA Lenz, TR Miller, H Ma - Chemosphere, 2019 - Elsevier
Cyanobacterial blooms represent a significant risk to environmental and human health due
to their production of toxic secondary metabolites, cyanopeptides. Anabaenopeptins and …

Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation

Y Tan, J Liu, Y Deng, H Cao, D Xu, F Cu, Y Lei… - Toxicology letters, 2012 - Elsevier
Several epidemiological investigations, including previous work by our laboratory, indicate
that maternal caffeine consumption is associated with intrauterine growth retardation and …

Critical role of the maternal immune system in the pathogenesis of autism spectrum disorder

D Ravaccia, T Ghafourian - Biomedicines, 2020 - mdpi.com
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders
characterised by impairments in communication, social interaction, and the presence of …