Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

Background Pancreatic cancer is characterized by extensive metastasis. Epithelial-
mesenchymal transition (EMT) plasticity plays a critical role in tumor progression and …

Mounting evidence suggests that platelets play an essential role in cancer metastasis. The
interactions between platelets and circulating tumor cells (CTCs) promote cancer …

The main role of platelets is to control bleeding and repair vascular damage via thrombosis.
They have also been implicated to promote tumor metastasis through platelet-tumor cell …

Glycosylation changes are key molecular events in tumorigenesis, progression and
glycosyltransferases play a vital role in the this process. FUT8 belongs to the …

Integrins, a group of heterodimer receptors for cell-matrix and cell-cell adhesion, mediate
various intracellular activities, including cell migration, polarity, survival, growth, and death …

Background Cancer development is strictly correlated to composition and physical
properties of the extracellular matrix. Particularly, a higher matrix stiffness has been …

Introduction Paclitaxel is a powerful and effective anti-tumor drug with wide clinical
application. However, there are still some limitations, including poor water solubility, low …

Castration-resistant prostate cancer (CRPC) is an aggressive lethal form of prostate cancer
(PCa). Atraric acid (AA) not only inhibits the wild-type androgen receptor (AR) but also those …