Role and therapeutic target of P2X2/3 receptors in visceral pain

H Luo, J Ye, F Pu, H Luo, W Zhang - Neuropeptides, 2023 - Elsevier
Visceral pain (VP) is caused by internal organ disease. VP is involved in nerve conduction
and related signaling molecules, but its specific pathogenesis has not yet been fully …

Reprogramming adipose mesenchymal stem cells into islet β-cells for the treatment of canine diabetes mellitus

P Dai, G Qi, H Xu, M Zhu, J Li, Y Chen, L Zhang… - Stem Cell Research & …, 2022 - Springer
Background Islet transplantation is an excellent method for the treatment of type I diabetes
mellitus. However, due to the limited number of donors, cumbersome isolation and …

Ropivacaine-induced seizures evoked pain sensitization in rats: participation of 5-HT/5-HT3R

CL Yang, JJ Jing, SY Fu, YL Zhong, XZ Su, ZM Shi… - Neurotoxicology, 2022 - Elsevier
Due to the increasing use of local anesthetic techniques in various healthcare settings, local
anesthetic toxicity still occurs. Seizures are the most common symptom of local anesthetic …

The Preventive Effect of Urinary Trypsin Inhibitor on Postoperative Cognitive Dysfunction, on the Aspect of Behavior, Evaluated by Y-Maze Test, via Modulation of …

EH Cho, CB In, GW Lee, SW Hong, EH Seo… - International Journal of …, 2024 - mdpi.com
This experimental study was designed to evaluate the effect of ulinastatin, a urinary trypsin
inhibitor, on postoperative cognitive dysfunction (POCD) in rats under general anesthesia …

Medial and dorsal lateral septum involving social disruption stress-primed escalation in acid-induced writhes

YH Liao, LH Sun, YC Su, WJ Yao, L Yu - Frontiers in Molecular …, 2023 - frontiersin.org
Stress may cause prospective escalations in abdominal pain magnitude and accumbal
TRPV1 expression, while central neural circuits mediating these stress effects remain …

The analgesic effects of ulinastatin either as a single agent or in combination with sufentanil: A novel therapeutic potential for postoperative pain

ZB Guo, L Tang, LP Wang, HH Wu, CL Huang… - European Journal of …, 2021 - Elsevier
Ulinastatin is a broad-spectrum protease inhibitor widely used for the treatment of various
inflammation-related diseases owing to its recognized excellent anti-inflammatory and …

Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain

M Defaye, C Altier - Visceral Pain, 2023 - Springer
Abdominal pain is one of the main symptoms of chronic gastrointestinal disorders including
inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS). The pathological …