Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Highlights•Protein O-fucosyltransferases 1 and 2 (POFUT1 and POFUT2) are ER-localized
and modify EGF repeats and TSRs.•Both POFUT1 and POFUT2 are exquisitely selective for …

Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form
beaded microfibrils which are essential components of most extracellular matrices. Fibrillin …

A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases
are secreted metalloproteinases that play key roles in the formation, homeostasis and …

Carpal tunnel syndrome (CTS) is a common and disabling condition of the hand caused by
entrapment of the median nerve at the level of the wrist. It is the commonest entrapment …

Proteases are a diverse group of hydrolytic enzymes, ranging from single-domain catalytic
molecules to sophisticated multi-functional macromolecules. Human proteases are divided …

ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and
angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the …

ADAMTS18 was identified in 2002 as a member of the ADAMTS family of 19 secreted Zinc-
dependent metalloproteinases. Prior to 2016, ADAMTS18 was known as a candidate gene …

Purpose Ocular anterior segment disorders (ASDs) are clinically and genetically
heterogeneous, and genetic diagnosis often remains elusive. In this study, we demonstrate …

Fibrillin is an evolutionarily ancient protein that lends elasticity and resiliency to a variety of
tissues. In humans, mutations in fibrillin-1 cause Marfan and related syndromes, conditions …