Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …

Astrocyte dysfunction has previously been linked to multiple neurodegenerative disorders
including Parkinson's disease (PD). Among their many roles, astrocytes are mediators of the …

Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected
individuals. Controlling the excessive production of pro-inflammatory cytokines and …

Both astrocytic and microglial functions have been extensively investigated in healthy
subjects and neurodegenerative diseases. For astrocytes, not only various sub-types were …

Background Impairment of the blood-brain barrier (BBB) is considered to be a common
feature among neurodegenerative diseases, including Alzheimer's, Parkinson's and prion …

Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …

Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Neurological disorders have been linked to a defective blood–brain barrier (BBB), with
dysfunctions triggered by stage-specific disease mechanisms, some of these being …