Disease mechanisms have become better understood in previously incurable forms of early-
onset severe retinal dystrophy, such as Leber congenital amaurosis (LCA). This has led to …

With the identification of novel targets, the number of interventional clinical trials in
ophthalmology has increased. Visual acuity has for a long time been considered the gold …

The pervasiveness of mobile devices and other associated technologies has affected all
aspects of our daily lives. People with visual impairments are no exception, as they …

Signaling of vision to the brain starts with the retinal phototransduction cascade which
converts visible light from the environment into chemical changes. Vision impairment results …

Geographic atrophy (GA) is a vision-threatening manifestation of age-related macular
degeneration (AMD), one of the leading causes of blindness globally. Objective, rapid …

Purpose To assess the safety and efficacy of AAV8-hCARp. hCNGB3 in participants with
CNGB3-associated achromatopsia (ACHM). Design Prospective, phase 1/2 …

Choroideremia is an X-linked retinal degeneration resulting from the progressive, centripetal
loss of photoreceptors and choriocapillaris, secondary to the degeneration of the retinal …

Purpose An intravitreally injected antisense oligonucleotide, sepofarsen, was designed to
modulate splicing within retinas of patients with severe vision loss due to deep intronic c …

Objective To report the prevalence and contributing factors of undiagnosed diabetic
retinopathy (DR) in a population from Northeastern China. Subjects/Methods A total of 800 …

Methods A 27-item questionnaire (the dog variable lighting questionnaire, dogVLQ) was
designed to assess visual behavior in dogs in different lighting settings. We conducted the …