Melatonin research has been experiencing hyper growth in the last two decades; this relates
to its numerous physiological functions including anti-inflammation, oncostasis, circadian …

Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450
epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic …

The generation of nephrons during development depends on differentiation via a
mesenchymal to epithelial transition (MET) of self-renewing, tissue-specific stem cells …

Identification of tissue‐specific renal stem/progenitor cells with nephrogenic potential is a
critical step in developing cell‐based therapies for renal disease. In the human kidney …

Objectives Kidney disease is emerging as a critical medical problem worldwide. Because of
limited treatment options for the damaged kidney, stem cell treatment is becoming an …

When assembling a nephron during development a multipotent stem cell pool becomes
restricted as differentiation ensues. A faulty differentiation arrest in this process leads to …

Mesenchymal stromal cells (MSC) have shown immunomodulatory and tissue repair
potential including partial tolerance induction by pre-treatment of donor-specific cells in a rat …

During nephrogenesis, stem/progenitor cells differentiate and give rise to early nephron
structures that segment to proximal and distal nephron cell types. Previously, we …

The mammalian kidney is a highly complex organ, composed of various cell types within a
unique structural framework. Nonetheless, in recent years, giant leaps in our understanding …

Upscaling of kidney epithelial cells is crucial for renal regenerative medicine. Nonetheless,
the adult kidney lacks a distinct stem cell hierarchy, limiting the ability to long-term propagate …