Triple-negative breast cancer molecular subtyping and treatment progress

L Yin, JJ Duan, XW Bian, S Yu - Breast Cancer Research, 2020 - Springer
Triple-negative breast cancer (TNBC), a specific subtype of breast cancer that does not
express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth …

Neoadjuvant treatment for triple negative breast cancer: recent progresses and challenges

JS Lee, SE Yost, Y Yuan - Cancers, 2020 - mdpi.com
Triple negative breast cancer (TNBC) is an aggressive breast cancer with historically poor
outcomes, primarily due to the lack of effective targeted therapies. The tumor molecular …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of breast cancer

LA Emens, S Adams, A Cimino-Mathews… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Breast cancer has historically been a disease for which immunotherapy was largely
unavailable. Recently, the use of immune checkpoint inhibitors (ICIs) in combination with …

Artificial intelligence reveals features associated with breast cancer neoadjuvant chemotherapy responses from multi-stain histopathologic images

Z Huang, W Shao, Z Han, AM Alkashash… - NPJ Precision …, 2023 - nature.com
Advances in computational algorithms and tools have made the prediction of cancer patient
outcomes using computational pathology feasible. However, predicting clinical outcomes …

The clinical promise of immunotherapy in triple-negative breast cancer

P Vikas, N Borcherding, W Zhang - Cancer management and …, 2018 - Taylor & Francis
Triple-negative breast cancer (TNBC) is a heterogeneous disease with poorer outcomes
compared to other breast cancer subtypes. Contributing to the worse prognosis in TNBC is …

Prognostic and clinicopathological value of PD-L1 expression in primary breast cancer: a meta-analysis

W Huang, R Ran, B Shao, H Li - Breast cancer research and treatment, 2019 - Springer
Purpose To evaluate the association between PD-L1 expression (PD-L1+) and
clinicopathological characteristics and effect on prognosis in primary breast cancer (PBC) …

Update on prognostic and predictive biomarkers of breast cancer

Y Hou, Y Peng, Z Li - Seminars in diagnostic pathology, 2022 - Elsevier
Breast cancer represents a heterogeneous group of human cancer at both histological and
molecular levels. Estrogen receptor (ER), progesterone receptor (PR) and human epidermal …

Analysis of PD1, PDL1, PDL2 expression and T cells infiltration in 1014 gastric cancer patients

X Xing, J Guo, G Ding, B Li, B Dong, Q Feng, S Li… - …, 2018 - Taylor & Francis
Although immune checkpoint blockade have demonstrated promising results, their effects on
gastric cancer (GC) are under investigation. Understanding the clinical significance of PD1 …

Tumor microenvironment: key players in triple negative breast cancer immunomodulation

H Zheng, S Siddharth, S Parida, X Wu, D Sharma - Cancers, 2021 - mdpi.com
Simple Summary The tumor microenvironment (TME) is a complicated network composed of
various cells, signaling molecules, and extra cellular matrix. TME plays a crucial role in triple …

[HTML][HTML] Novel uses of immunohistochemistry in breast pathology: interpretation and pitfalls

A Cimino-Mathews - Modern Pathology, 2021 - Elsevier
Immunohistochemistry is an essential component of diagnostic breast pathology. The
emergence of novel assays and applications is accompanied by new interpretation criteria …