How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

Chromatin architecture has been implicated in cell type-specific gene regulatory programs,
yet how chromatin remodels during development remains to be fully elucidated. Here, by …

The recent development of spatial omics methods has enabled single-cell profiling of the
transcriptome and 3D genome organization with high spatial resolution. Expanding the …

The three-dimensional configuration of DNA is integral to all nuclear processes in
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …

Retinal ganglion cells (RGCs) convey the major output of information collected from the eye
to the brain. Thirty subtypes of RGCs have been identified to date. Here, we analyze 6225 …

A complete chart of cis-regulatory elements and their dynamic activity is necessary to
understand the transcriptional basis of differentiation and function of an organ system. We …