Summary Interferon-γ (IFN-γ)-mediated adaptive resistance is one major barrier to improving
immunotherapy in solid tumors. However, the mechanisms are not completely understood …

How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …

High-order chromatin structure plays important roles in gene expression regulation.
Knowledge of the dynamics of 3D chromatin structures during mammalian embryo …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

In mammals, chromatin organization undergoes drastic reprogramming after fertilization.
However, the three-dimensional structure of chromatin and its reprogramming in …

Intestinal Th17 cells are induced and accumulate in response to colonization with a
subgroup of intestinal microbes such as segmented filamentous bacteria (SFB) and certain …

Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Folding of mammalian genomes into spatial domains is critical for gene regulation. The
insulator protein CTCF and cohesin control domain location by folding domains into loop …

Diverse cell types in tissues have distinct gene expression programs, chromatin states, and
nuclear architectures. To correlate such multimodal information across thousands of single …