Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes
Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
A high-resolution map of the three-dimensional chromatin interactome in human cells
A large number of cis-regulatory sequences have been annotated in the human genome,,
but defining their target genes remains a challenge. One strategy is to identify the long …
but defining their target genes remains a challenge. One strategy is to identify the long …
Breaking TADs: how alterations of chromatin domains result in disease
Spatial organization is an inherent property of the vertebrate genome to accommodate the
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …
RNA binding to CBP stimulates histone acetylation and transcription
CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-
regulatory elements that control patterns of gene expression in multicellular organisms …
regulatory elements that control patterns of gene expression in multicellular organisms …
Loss of extreme long-range enhancers in human neural crest drives a craniofacial disorder
Non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene
result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a …
result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a …
The pioneer transcription factor FoxA maintains an accessible nucleosome configuration at enhancers for tissue-specific gene activation
M Iwafuchi-Doi, G Donahue, A Kakumanu, JA Watts… - Molecular cell, 2016 - cell.com
Nuclear DNA wraps around core histones to form nucleosomes, which restricts the binding
of transcription factors to gene regulatory sequences. Pioneer transcription factors can bind …
of transcription factors to gene regulatory sequences. Pioneer transcription factors can bind …
Global epigenomic reconfiguration during mammalian brain development
Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …
during brain development, maturation, and learning. DNA methylation (mC) is a stable …
CTCF shapes chromatin structure and gene expression in health and disease
B Dehingia, M Milewska, M Janowski, A Pękowska - EMBO reports, 2022 - embopress.org
CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
The transcription factor Myc is essential for the regulation of haematopoietic stem cells and
progenitors and has a critical function in haematopoietic malignancies. Here we show that …
progenitors and has a critical function in haematopoietic malignancies. Here we show that …