Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

Mapping chromatin loops from noisy Hi-C heatmaps remains a major challenge. Here we
present DeepLoop, which performs rigorous bias correction followed by deep-learning …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Regulation by gene-distal enhancers is critical for cell type-specific and condition-specific
patterns of gene expression. Thus, to understand the basis of gene activity in a given cell …

In this study, we present integrated quantitative proteome, transcriptome, and methylome
analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) …

A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …

Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct
conversions between differentiated cell lineages represent powerful approaches to engineer …

Genetic variation associated with disease often appears in non-coding parts of the genome.
Understanding the mechanisms by which this phenomenon leads to disease is necessary to …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

The circadian clock and associated feeding rhythms have a profound impact on metabolism
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …