Multiple knockout mouse models reveal lincRNAs are required for life and brain development
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few
have been tested for in vivo relevance through genetic ablation in animal models. To …
have been tested for in vivo relevance through genetic ablation in animal models. To …
A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome
Although major advances in genomics have initiated an exciting new era of research, a lack
of information regarding cis-regulatory elements has limited the genetic improvement or …
of information regarding cis-regulatory elements has limited the genetic improvement or …
The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements
The mammalian genome harbors up to one million regulatory elements often located at
great distances from their target genes. Long-range elements control genes through …
great distances from their target genes. Long-range elements control genes through …
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
P Langfelder, JP Cantle, D Chatzopoulou… - Nature …, 2016 - nature.com
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's
disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue …
disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue …
Enhancers: five essential questions
LA Pennacchio, W Bickmore, A Dean… - Nature Reviews …, 2013 - nature.com
Although enhancers are crucial and widespread gene-regulatory elements, we are far from
a complete understanding of how they function or their importance in areas such as disease …
a complete understanding of how they function or their importance in areas such as disease …
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
Topological-associated domains (TADs) are thought to be relatively stable across cell types,
although some TAD reorganization has been observed during cellular differentiation …
although some TAD reorganization has been observed during cellular differentiation …
Epigenomic analysis of multilineage differentiation of human embryonic stem cells
Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …
development, but their precise functions are only partially understood. To investigate …
Programming and inheritance of parental DNA methylomes in mammals
The reprogramming of parental methylomes is essential for embryonic development. In
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …
DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …