Cell-type-and condition-specific profiles of gene expression require coordination between
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …

The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC)
pluripotency by silencing lineage-specifying developmental regulator genes. Emerging …

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible
to the transcriptional machinery to allow appropriate expression of genes in different cell …

Cell-free DNA (cf. DNA) is a powerful noninvasive biomarker for cancer and prenatal testing,
and it circulates in plasma as short fragments. To elucidate the biology of cf. DNA …

Poly [adenosine diphosphate (ADP)–ribose] polymerases (PARPs) are a family of enzymes
that modulate diverse biological processes through covalent transfer of ADP-ribose from the …

Mutations in gene regulatory elements have been associated with a wide range of complex
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …

Current methods for epigenomic profiling are limited in their ability to obtain genome-wide
information with spatial resolution. We introduce spatial ATAC, a method that integrates …

Over the last decade, development and application of a set of molecular genomic
approaches based on the chromosome conformation capture method (3C), combined with …

Type 2 diabetes affects over 300 million people, causing severe complications and
premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic …

Formation and segregation of cell lineages forming the heart have been studied extensively
but the underlying gene regulatory networks and epigenetic changes driving cell fate …