Background Understanding the relationship between the millions of functional DNA
elements and their protein regulators, and how they work in conjunction to manifest diverse …

With the explosion of genome-wide studies of regulated transcription, it has become clear
that traditional definitions of enhancers and promoters need to be revisited. These control …

Long-range regulatory interactions play an important role in shaping gene-expression
programs. However, the genomic features that organize these activities are still poorly …

Recent studies have shown that chromosomes in a range of organisms are
compartmentalized in different types of chromatin domains. In mammals, chromosomes form …

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms
remain elusive. We hypothesized that a diet that changes methyl donor availability will alter …

RNA-Seq data analysis results in lists of genes that may have a similar function, based on
differential gene expression analysis or co-expression network analysis. While tools have …

Gene expression during development and differentiation is regulated in a cell-and stage-
specific manner by complex networks of intergenic and intragenic cis-regulatory elements …

CTCF is an architectural protein with a critical role in connecting higher-order chromatin
folding in pluripotent stem cells. Recent reports have suggested that CTCF binding is more …

Transcriptional enhancers are crucial regulators of gene expression and animal
development and the characterization of their genomic organization, spatiotemporal …

As the second dimension to the genome, the epigenome contains key information specific to
every type of cells. Thousands of human epigenome maps have been produced in recent …