T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
[HTML][HTML] DCs at the center of help: Origins and evolution of the three-cell-type hypothesis
Last year was the 10th anniversary of Ralph Steinman's Nobel Prize awarded for his
discovery of dendritic cells (DCs), while next year brings the 50th anniversary of that …
discovery of dendritic cells (DCs), while next year brings the 50th anniversary of that …
Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of …
S Sakaguchi, K Fukuma, K Kuribayashi… - The Journal of …, 1985 - rupress.org
Organ-specific autoimmune diseases such as oophoritis, gastritis, thyroiditis, and orchitis
were induced in female or male nude (nu/nu) mice by the transfer of nu/+ spleen cells from …
were induced in female or male nude (nu/nu) mice by the transfer of nu/+ spleen cells from …
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process …
H Cantor, EA Boyse - The Journal of experimental medicine, 1975 - rupress.org
Ly alloantigens coded by two unlinked genetic loci (Ly-1 and Ly-2/Ly-3) are expressed on
lymphoid cells undergoing thymus-dependent differentiation. Peripheral Thy-1+ cells from …
lymphoid cells undergoing thymus-dependent differentiation. Peripheral Thy-1+ cells from …
Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells
PD Greenberg - Advances in immunology, 1991 - Elsevier
Publisher Summary This chapter attempts to identify the principles and issues elucidated in
animal models that may provide insights for the development of effective approaches to …
animal models that may provide insights for the development of effective approaches to …
Cancer immunology: the search for specificity—GHA Clowes Memorial lecture
LJ Old - Cancer research, 1981 - AACR
The major focus of cancer immunology has shifted away from arguments about the validity of
the immunosurveillance theory of cancer to the more basic question of tumor-specific …
the immunosurveillance theory of cancer to the more basic question of tumor-specific …
Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.
H Cantor, EA Boyse - The Journal of experimental medicine, 1975 - rupress.org
Lymphocytes from BALB/c or C57B6/6 mice that develop killer activity to alloantigens belong
to the numerically small Ly-23 subclass of peripheral T cells, distinguished by selective …
to the numerically small Ly-23 subclass of peripheral T cells, distinguished by selective …
T cell subsets defined by expression of Lyt-1, 2, 3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies …
JA Ledbetter, RV Rouse, HS Micklem… - The Journal of …, 1980 - rupress.org
Using monoclonal antibodies and multiparameter fluorescence analyses, we show that the
expression of Lyt-1, Lyt-2, and Lyt-3 on T cell subpopulations is more complex than was …
expression of Lyt-1, Lyt-2, and Lyt-3 on T cell subpopulations is more complex than was …
Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and …
H Cantor, FW Shen, EA Boyse - The Journal of experimental medicine, 1976 - rupress.org
Cells of the Lyl subclass generate helper activity in both primary and secondary responses
to sheep erythrocytes (SRBC). In contrast, after priming with SRBC, cells of the Ly-2+ …
to sheep erythrocytes (SRBC). In contrast, after priming with SRBC, cells of the Ly-2+ …
Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man
JA Ledbetter, RL Evans, M Lipinski… - The Journal of …, 1982 - rupress.org
We describe the biochemical properties and cell surface distributions of three human T cell
antigens (Leu-1, Leu-2a, and Leu-2b) which we postulate to be the homologues of the Lyt-1 …
antigens (Leu-1, Leu-2a, and Leu-2b) which we postulate to be the homologues of the Lyt-1 …