Abstract In the United States, exposure to human-biting ixodid ticks can occur while
spending time on residential properties or in neighborhood green spaces as well as during …

Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …

Lyme disease is the most common vector-borne infectious disease in the United States, in
part because a vaccine against it is not currently available for humans. We propose utilizing …

The Lyme disease (LD) vaccine formerly approved for use in the United States consisted of
recombinant outer surface protein A (OspA) from Borrelia burgdorferi sensu stricto (ss), the …

ABSTRACT The only United States Food and Drug Administration approved vaccine
preparation to prevent Lyme disease consisted of a single recombinant outer surface protein …

The deer tick transmits nearly half of the known tick-borne pathogens in the United States,
and its expanding geographic range increases the risk of human infection. To decrease the …

44 is a human monoclonal antibody capable of passively protecting mice against tick‐
mediated infection with Borreliella burgdorferi, the bacterial genospecies responsible for …

ABSTRACT Introduction Transmitted by ticks, Lyme disease is the most common vector-
borne disease in the Northern hemisphere. Despite the geographical expansion of human …

Introduction Borrelia burgdorferi sensu lato (sl) is the causative agent of Lyme borreliosis.
Currently there is no human vaccine against Lyme borreliosis, and most research focuses …

The blacklegged tick, Ixodes scapularis, is the predominant vector of Borrelia burgdorferi,
the agent of Lyme disease in the USA. Natural hosts of I. scapularis such as Peromyscus …