The mesolimbic dopamine system in chronic pain and associated affective comorbidities
RA Serafini, KD Pryce, V Zachariou - Biological psychiatry, 2020 - Elsevier
Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …
and affective symptoms. Over the past 2 decades, researchers have made significant …
Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
S Wang, F Leri, SJ Rizvi - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
Influences of dopaminergic system dysfunction on late-life depression
Deficits in cognition, reward processing, and motor function are clinical features relevant to
both aging and depression. Individuals with late-life depression often show impairment …
both aging and depression. Individuals with late-life depression often show impairment …
Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression
The efficacy of dopamine agonists in treating major depressive disorder has been
hypothesized to stem from effects on ventrostriatal dopamine and reward function. However …
hypothesized to stem from effects on ventrostriatal dopamine and reward function. However …
Multilevel growth curve analyses of behavioral activation for anhedonia (BATA) and mindfulness-based cognitive therapy effects on anhedonia and resting-state …
P Cernasov, EC Walsh, JL Kinard, L Kelley… - Journal of Affective …, 2021 - Elsevier
Background The neural mechanisms associated with anhedonia treatment response are
poorly understood. Additionally, no study has investigated changes in resting-state …
poorly understood. Additionally, no study has investigated changes in resting-state …
Striatal dopamine in anhedonia: A simultaneous [11C] raclopride positron emission tomography and functional magnetic resonance imaging investigation
Background Anhedonia is hypothesized to be associated with blunted mesocorticolimbic
dopamine (DA) functioning in samples with major depressive disorder. The purpose of this …
dopamine (DA) functioning in samples with major depressive disorder. The purpose of this …
Dopamine in major depressive disorder: A systematic review and meta-analysis of in vivo imaging studies
Background: Major depressive disorder (MDD) is a leading cause of global disability.
Several lines of evidence implicate the dopamine system in its pathophysiology. However …
Several lines of evidence implicate the dopamine system in its pathophysiology. However …
Angiotensin blockade enhances motivational reward learning via enhancing striatal prediction error signaling and frontostriatal communication
Adaptive human learning utilizes reward prediction errors (RPEs) that scale the differences
between expected and actual outcomes to optimize future choices. Depression has been …
between expected and actual outcomes to optimize future choices. Depression has been …
Brain structural abnormalities in adult major depressive disorder revealed by voxel-and source-based morphometry: evidence from the REST-meta-MDD Consortium
Background Neuroimaging studies on major depressive disorder (MDD) have identified an
extensive range of brain structural abnormalities, but the exact neural mechanisms …
extensive range of brain structural abnormalities, but the exact neural mechanisms …
Advances in simultaneous PET/MR for imaging neuroreceptor function
Hybrid imaging using PET/MRI has emerged as a platform for elucidating novel
neurobiology, molecular and functional changes in disease, and responses to physiological …
neurobiology, molecular and functional changes in disease, and responses to physiological …