Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …

Background Alzheimer's disease (AD) is highly intertwined with sleep disturbances
throughout its whole natural history. Sleep consists of a major compound of the functionality …

Humans are exposed to extreme environmental stressors during spaceflight and return with
alterations in brain structure and shifts in intracranial fluids. To date, no studies have …

Objectives Perivascular spaces have been involved in neuroinflammatory and
neurodegenerative diseases. Upon a certain size, these spaces can become visible on …

Perivascular spaces (PVS) and their enlargement (EPVS) have been gaining interest as
EPVS can be visualized non-invasively by magnetic resonance imaging (MRI) when viewing …

The brain endothelial cell (BEC) glycocalyx (ecGCx) is a BEC surface coating consisting of a
complex interwoven polysaccharide (sweet husk) mesh-like network of membrane-bound …

Embryonic genetic mechanisms are present in the brain and ready to be placed into action
upon cellular injury, termed the response to injury wound-healing (RTIWH) mechanism …

Background and Objectives Enlarged perivascular spaces (ePVS) have been identified as a
key signature of glymphatic system dysfunction in neurologic conditions. The incidence and …

The blood–brain barrier (BBB) undergoes functional changes with aging which may
contribute to cognitive decline. A novel, diffusion prepared arterial spin labeling-based MRI …

Background Perivascular spaces (PVS) are fluid-filled compartments that dilate in response
to many different conditions. A high burden of enlarged PVS (EPVS) in the centrum …