Thrombin is the pivotal enzyme in the biochemistry of secondary hemostasis crucial to
maintaining homeostasis of hemostasis. In contrast to routine coagulation tests (PT or aPTT) …

Treatment of bleeding and thrombotic disorders is highly standardized and based on
evidence-based medicine guidelines. These evidence-based treatment schemes are well …

International normalized ratio (INR) is the preferred test of choice for patients taking vitamin
K antagonists (VKA). It can also be used to assess the risk of bleeding or the coagulation …

Rivaroxaban is excreted from the body via multiple pathways involving glomerular filtration,
drug‐metabolizing enzymes and transporters. In this study, we aimed to examine the impact …

Edoxaban is a direct oral anticoagulant (DOAC) that has been recently indicated for the
treatment of pulmonary embolism (PE) in SARS-CoV-2 infections. Due to its …

Introduction ABCB1 gene polymorphisms are associated with rivaroxaban distribution
changes and adverse reactions but the data are controversial. Aim To evaluate the influence …

Background Direct oral anticoagulants (DOACs) are increasingly used worldwide. Little is
known so far about their pharmacokinetics in emergency situations. Methods A prospective …

Objectives For revealing the peculiarities of the drug–drug interaction of rivaroxaban
(substrate CYP3A4 and P-gp) and calcium channel blockers (CCBs)(verapamil–inhibitor …

Although the monitoring of drug therapies based on the determination of drug
concentrations in biological materials is certainly an important instrument for individualized …

Background Investigations into the rivaroxaban response from the perspective of genetic
variation have been relatively recent and wide in scope, whereas there is no consensus on …