Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism

J Zieba, D Sinclair, T Sebree, M Bonn-Miller… - Pharmacology …, 2019 - Elsevier
Fragile X Syndrome is a neurodevelopmental disorder which affects intellectual, social and
physical development due to mutation of the Fragile X mental retardation 1 (FMR1) gene …

Phytocannabinoids and epilepsy

RG Dos Santos, JEC Hallak, JP Leite… - Journal of clinical …, 2015 - Wiley Online Library
What is known and objective Antiepileptic drugs often produce serious adverse effects, and
many patients do not respond to them properly. Phytocannabinoids produce anticonvulsant …

Pediatric concerns due to expanded cannabis use: unintended consequences of legalization

GS Wang - Journal of Medical Toxicology, 2017 - Springer
An “unintended consequence” of marijuana legalization is the impact on the pediatric
population. From prenatal exposure to unintentional childhood exposures, through concerns …

Antiseizure effects of cannabidiol leading to increased peroxisome proliferator-activated receptor gamma levels in the hippocampal CA3 subfield of epileptic rats

AM Costa, F Russo, L Senn, D Ibatici, G Cannazza… - Pharmaceuticals, 2022 - mdpi.com
We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-
activated receptor gamma (PPARγ) levels in an animal model of temporal lobe epilepsy …

Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se

AJ Hill, NA Jones, I Smith, CL Hill, CM Williams… - Neuroscience …, 2014 - Elsevier
Cannabidiol (CBD) is a non-psychoactive, well-tolerated, anticonvulsant plant cannabinoid,
although its mechanism (s) of seizure suppression remains unknown. Here, we investigate …

Cannabidiol and neurodevelopmental disorders in children

KA Kwan Cheung, MD Mitchell, HS Heussler - Frontiers in Psychiatry, 2021 - frontiersin.org
Neurodevelopmental and neuropsychiatric disorders (such as autism spectrum disorder)
have broad health implications for children, with no definitive cure for the vast majority of …

Preclinical safety and efficacy of cannabidivarin for early life seizures

MN Huizenga, A Sepulveda-Rodriguez, PA Forcelli - Neuropharmacology, 2019 - Elsevier
A significant proportion of neonatal and childhood seizures are poorly controlled by existing
anti-seizure drugs (ASDs), likely due to prominent differences in ionic homeostasis and …

A resurging boom in new drugs for epilepsy and brain disorders

I Younus, DS Reddy - Expert review of clinical pharmacology, 2018 - Taylor & Francis
Introduction: Epilepsy is one of the most common neurological diseases affecting
approximately 50 million people worldwide. Despite many advances in epilepsy research …

Treatment of infantile spasms

SA Hussain - Epilepsia open, 2018 - Wiley Online Library
The treatment of infantile spasms is challenging, especially in the context of the following:(1)
a severe phenotype with high morbidity and mortality;(2) the urgency of diagnosis and …

Potential anti-epileptic phytoconstituents: An updated review

J Kaur, P Famta, M Famta, M Mehta, S Satija… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Epilepsy is one of the most commonly occurring non-
communicable neurological disorder that affects people of all age groups. Around 50 million …