The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …

The identification of molecular agents inhibiting specific functions in cancer cells
progression is considered as one of the most successful plans in cancer treatment. The …

Epidermal growth factor receptor (EGFR) is a vital intermediate in cell signaling pathway
including cell proliferation, angiogenesis, apoptosis, and metastatic spread and also having …

Three generations of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-
TKIs) have been developed for treating advanced/metastatic non-small cell lung cancer …

Glioma is a malignant form of brain cancer that is challenging to treat due to the progressive
growth of glial cells. To target overexpressed folate receptors in glioma brain tumors, we …

Tyrosine kinases are known to play a role in tumour growth and proliferation, and they have
become common drug targets. Tyrosine kinase inhibitors (TKIs) prohibit associated kinases …

Chinese herbal medicine (CHM) has been widely used in the treatment of advanced non-
small-cell lung cancer (NSCLC), but their efficacy and safety remain controversial. We …

Tyrosine kinase inhibitor (TKI) treatment is the first-line therapy for non-small cell lung
cancer (NSCLC) caused by activating mutations of epidermal growth factor receptor (EGFR) …

The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers,
contribute to oncogenesis by corrupting the mRNA splicing. Further SF3B1 mutations have …

Aim: This paper aims to describe the structure activity relationship of heterocyclic derivatives
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …