Moving toward a new horizon for the aldose reductase inhibitor epalrestat to treat drug-resistant cancer
C Bailly - European Journal of Pharmacology, 2022 - Elsevier
Epalrestat (EPA) is a potent inhibitor of aldose reductases AKR1B1 and AKR1B10, used for
decades in Japan for the treatment of diabetic peripheral neuropathy. This orally-active …
decades in Japan for the treatment of diabetic peripheral neuropathy. This orally-active …
[HTML][HTML] N-Acetylcysteine overcomes epalrestat-mediated increase of toxic 4-hydroxy-2-nonenal and potentiates the anti-arthritic effect of epalrestat in AIA model
L Wang, B Huang, Y Zeng, J Yang, Z Li… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Epalrestat, an aldose reductase inhibitor (ARI), has been clinically adopted in treating
diabetic neuropathy in China and Japan. Apart from the involvement in diabetic …
diabetic neuropathy in China and Japan. Apart from the involvement in diabetic …
Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota
Y Hu, S Chen, W Yan, L Ji, M Shao, Z Sun, D He… - eFood, 2023 - Wiley Online Library
Rape (Brassica napus L.) bee pollen (RBP) is a functional food rich in nutrients obtained by
worker bees collecting rape pollen and mixing it with nectar and bee salivary enzymes. The …
worker bees collecting rape pollen and mixing it with nectar and bee salivary enzymes. The …
LncRNA CRNDE is involved in the pathogenesis of renal fibrosis by regulating renal epithelial cell mesenchymal-epithelial transition via targeting miR-29a-3p
M Zhao, N Li, C Wan, Q Zhang, H Wang… - … Molecular Mechanisms of …, 2023 - Elsevier
Results of previous studies suggested that renal fibrosis and epithelial-mesenchymal
transition (EMT) plays an important role in the process of renal fibrosis, but the underlying …
transition (EMT) plays an important role in the process of renal fibrosis, but the underlying …
Metabolomics and molecular dynamics unveil the therapeutic potential of epalrestat in diabetic nephropathy
T Song, R Wang, X Zhou, W Chen, Y Chen, Z Liu… - International …, 2024 - Elsevier
Diabetic nephropathy (DN) is one of the leading clinical causes of end-stage renal failure.
The classical aldose reductase (AR) inhibitor epalrestat shows beneficial effect on renal …
The classical aldose reductase (AR) inhibitor epalrestat shows beneficial effect on renal …