The safety issues like immunogenicity and unacceptable cancer risk of viral vectors for
DNA/mRNA vaccine delivery necessitate the development of non-viral vectors with no …

Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although
chemotherapy remains the mainstay of cancer therapy, non-selective toxicity and drug …

Accumulating evidence indicates that oxidative stress and inflammation are involved in the
physiopathology of liver fibrogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a …

Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

Gene delivery systems play a vital role in gene therapy and recombinant protein production.
The advantages of using gene delivery reagents for non-viral vector include the capacity to …

Proximity labeling (PL) has emerged as a powerful approach to elucidate proteomes within
a defined radius around a protein of interest (POI). In PL, a catalyst is attached to the POI …

Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …

Organelles are specialized subunits within a cell membrane that perform specific roles or
functions, and their dysfunction can lead to a variety of pathophysiologies including …

The potential of nucleic acid therapeutics to treat diseases by targeting specific cells has
resulted in its increasing number of uses in clinical settings. However, the major challenge is …

Osteogenesis imperfecta (OI) is an uncommon genetic disorder characterized by shortness
of stature, hearing loss, poor bone mass, recurrent fractures, and skeletal abnormalities …