Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant
pathogenesis of early myocardial infarction (MI). However, only a few agents or strategies …

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the
efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current …

Ischemic heart failure (IHF) is a leading cause of morbidity and mortality worldwide, for
which heart transplantation remains the only definitive treatment. IHF manifests from …

The role of oxidative injury and inflammatory response in cardiovascular diseases and heart
failure has been well-acknowledged. This study evaluated the protective effect of …

Sinomenine (SIN), an alkaloid extracted from the root of S. acutum. sinomenine, has been
shown to have antiarrhythmic, antioxidant, and anti-inflammatory effects in myocardial …

Abstract Background Lagopsis supina (Steph. ex. Willd.) Ikonn.-Gal. is an important
traditional Chinese medicine used to treat various ailments. However, its impact on …

Abstract Rap1 GTPase-activating protein (Rap1GAP) is an important tumor suppressor. The
purpose of this study was to investigate the role of Rap1GAP in myocardial infarction (MI) …

Arrhythmic sudden cardiac death (SCD) is an important cause of mortality following
myocardial infarction (MI). The rabbit has similar cardiac electrophysiology to humans and is …

Endothelial cells (ECs) have essential roles in cardiac tissue repair after myocardial
infarction (MI). To establish stage-specific and long-term effects of the ischemic injury on …

Background Despite the success of interventional coronary reperfusion strategies, morbidity
and mortality from acute myocardial infarction are still substantial. Physical exercise is a well …