Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

Background Acute inflammation induced by reactive astrocytes after cerebral
ischemia/reperfusion (I/R) injury is important for protecting the resultant lesion. Our previous …

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Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

Uptake of glutamate from the extracellular space and glutamate release to neurons are two
major processes conducted by astrocytes in the central nervous system (CNS) that protect …

Regulatory Nod-like receptors (NLRs) are a subgroup of the cytosolic NLR family of
pathogen recognition receptors (PRRs). These receptors can tune the innate immune …

Myocardial infarction (MI) is a myocardial injury caused by coronary thrombosis or persistent
ischemia and hypoxia. Due to its high morbidity and mortality, a safer and more effective …

Temporomandibular joint osteoarthritis (TMJ OA) is an important subtype of
temporomandibular disorders (TMD). Articular cartilage destruction is considered a common …