Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Ion channels have been shown to be involved in oncogenesis and efforts are being poured
in to target the ion channels. There are many clinically approved drugs with ion channels as …

Background Harmaline and harmine are tremorigenic β-carbolines that, on administration to
experimental animals, induce an acute postural and kinetic tremor of axial and truncal …

The objective of this article is to review the application of informatics-driven approaches in
the pharmacovigilance field with focus on drug-drug interaction (DDI) safety signal discovery …

Abstract Background and objectives Pharmacovigilance (PhV) is an important clinical
activity with strong implications for population health and clinical research. The main goal of …

Innate and acquired resistances to therapeutic agents are responsible for the failure of
cancer treatments. Due to the multifactorial nature of resistance, the identification of new …

The cation channel of sperm (CatSper) comprises four transmembrane subunits specifically
expressed in human, equine, murine and ovine spermatozoa, apparently implicated in …

An increase in neuronal burst activities in the subthalamic nucleus (STN) is a well-
documented electrophysiological feature of Parkinson disease (PD). However, the causal …

CYP2D6 accounts for only a small percentage of total hepatic CYPs (100) with significant
polymorphisms. A number of drugs acting on the central nervous system and cardiovascular …