BRAF mutations in thyroid cancer

RS Scheffel, JM Dora, AL Maia - Current Opinion in Oncology, 2022 - journals.lww.com
The impact of BRAF mutations on the clinical outcomes of PTC remains debatable. In ATCs,
in turn, BRAF mutations identify patients eligible for targeted therapy, which is now …

The relationship between thyrotropin serum concentrations and thyroid carcinoma

X Zhang, L Tian, D Teng, W Teng - Cancers, 2023 - mdpi.com
Simple Summary Thyroid-stimulating hormone (TSH) plays a role in the regulation of thyroid
hormones and is an important indicator for assessing thyroid function. Thyroid cancer (TC) is …

Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma

X Zhang, Y Zhong, L Liu, C Jia, H Cai, J Yang… - Cell Death & …, 2023 - nature.com
Recurring evidence suggests that fasting has extensive antitumor effects in various cancers,
including papillary thyroid carcinoma (PTC). However, the underlying mechanism of this …

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

H Lasolle, A Schiavo, A Tourneur, P Gillotay… - Oncogene, 2024 - nature.com
Thyroid cancer is the most common endocrine malignancy and several genetic events have
been described to promote the development of thyroid carcinogenesis. Besides the effects of …

Could oxidative stress play a role in the development and clinical management of differentiated thyroid cancer?

M Kościuszko, A Buczyńska, AJ Krętowski… - Cancers, 2023 - mdpi.com
Simple Summary Increased oxidative stress (OS) has been implicated as a relevant risk
factor for cancer development and progression. The incidence of differentiated thyroid …

Management of radioiodine refractory differentiated thyroid cancer: the Latin American perspective

F Pitoia, RS Scheffel, I Califano, A Gauna… - Reviews in Endocrine …, 2024 - Springer
Radioiodine (RAI) refractory differentiated thyroid cancer is an uncommon and challenging
situation that requires a multidisciplinary approach to therapeutic strategies. The definition of …

The Presence of Typical “BRAFV600E-Like” Atypia in Papillary Thyroid Carcinoma is Highly Specific for the Presence of the BRAFV600E Mutation

J Turchini, L Sioson, A Clarkson, A Sheen… - Endocrine …, 2023 - Springer
Papillary thyroid carcinomas (PTCs) are driven by a variety of molecular abnormalities
including BRAF, RAS, ALK, RET, and NTRK alterations. PTCs driven by the BRAFV600E …

Treatment strategies for low-risk papillary thyroid carcinoma: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and …

LS Ward, RS Scheffel, AO Hoff, C Ferraz… - … of Endocrinology and …, 2022 - SciELO Brasil
Increasingly sensitive diagnostic methods, better understanding of molecular
pathophysiology, and well-conducted prospective studies have changed the current …

Risk stratification of papillary thyroid cancers using multidimensional machine learning

Y Li, F Wu, W Ge, Y Zhang, Y Hu, L Zhao… - … Journal of Surgery, 2024 - journals.lww.com
Background: Papillary thyroid cancer (PTC) is one of the most common endocrine
malignancies with different risk levels. However, preoperative risk assessment of PTC is still …

[Retracted] LncRNA‐PAX8‐AS1 Silencing Decreases Cell Viability, Enhances Apoptosis, and Suppresses Doxorubicin Resistance in Myeloid Leukemia via the miR …

X Song, Y Chen, Y Peng, X Wang… - Evidence‐Based …, 2022 - Wiley Online Library
Objective. Considering the role of lncRNAs reported as regulators in acute myeloid leukemia
(AML) progression, the current research aims to investigate the role of PAX8‐AS1 in chemo …