Physiological effect of ghrelin on body systems

Y Akalu, MD Molla, G Dessie… - International journal of …, 2020 - Wiley Online Library
Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of
physiological effects. In this review, we found/confirmed that ghrelin has effect on all body …

Is ghrelin synthesized in the central nervous system?

A Cabral, EJ Lopez Soto, J Epelbaum… - International journal of …, 2017 - mdpi.com
Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone
secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological …

Ghrelin receptors mediate ghrelin‐induced excitation of agouti‐related protein/neuropeptide Y but not pro‐opiomelanocortin neurons

SR Chen, H Chen, JJ Zhou, G Pradhan… - Journal of …, 2017 - Wiley Online Library
Ghrelin increases food intake and body weight by stimulating orexigenic agouti‐related
protein (Ag RP)/neuropeptide Y (NPY) neurons and inhibiting anorexic pro …

[HTML][HTML] Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior

EM Di Bonaventura, L Botticelli, F Del Bello… - Pharmacological …, 2021 - Elsevier
The peripheral peptide hormone ghrelin is a powerful stimulator of food intake, which leads
to body weight gain and adiposity in both rodents and humans. The hormone, thus …

The role of ghrelin in anorexia nervosa

MA Schalla, A Stengel - International journal of molecular sciences, 2018 - mdpi.com
Ghrelin, a 28-amino acid peptide hormone expressed in X/A-like endocrine cells of the
stomach, is the only known peripherally produced and centrally acting peptide that …

[HTML][HTML] Neuroendocrinological factors in binge eating disorder: A narrative review

I Baenas, R Miranda-Olivos, N Solé-Morata… - …, 2023 - Elsevier
Neuroendocrine mechanisms play a key role in the regulation of eating behavior. In
individuals with binge eating disorder (BED), alterations in these mechanisms signaling …

Circulating acyl and des-acyl ghrelin levels in obese adults: a systematic review and meta-analysis

Y Wang, Q Wu, Q Zhou, Y Chen, X Lei, Y Chen… - Scientific reports, 2022 - nature.com
Ghrelin is the only known orexigenic gut hormone, and its synthesis, secretion and
degradation are affected by different metabolic statuses. This meta-analysis aimed to …

Brain accessibility delineates the central effects of circulating ghrelin

M Perello, A Cabral, MP Cornejo… - Journal of …, 2019 - Wiley Online Library
Ghrelin is a hormone produced in the gastrointestinal tract that acts via the growth hormone
secretagogue receptor. In the central nervous system, ghrelin signalling is able to recruit …

[HTML][HTML] Control of food intake by gastrointestinal peptides: mechanisms of action and possible modulation in the treatment of obesity

P Prinz, A Stengel - Journal of Neurogastroenterology and Motility, 2017 - ncbi.nlm.nih.gov
This review focuses on the control of appetite by food intake-regulatory peptides secreted
from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY …

Evidence supporting a role for the blood-cerebrospinal fluid barrier transporting circulating ghrelin into the brain

M Uriarte, PN De Francesco, G Fernandez… - Molecular …, 2019 - Springer
The stomach-derived hormone ghrelin mainly acts in the brain. Studies in mice have shown
that the accessibility of ghrelin into the brain is limited and that it mainly takes place in some …