The potential role of curcumin in modulating the master antioxidant pathway in diabetic hypoxia-induced complications

S Ghareghomi, M Rahban, Z Moosavi-Movahedi… - Molecules, 2021 - mdpi.com
Oxidative stress is the leading player in the onset and development of various diseases. The
Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells' redox balance. It …

A state-of-the-art review on the NRF2 in Hepatitis virus-associated liver cancer

L Kalantari, ZR Ghotbabadi, A Gholipour… - Cell Communication and …, 2023 - Springer
According to a paper released and submitted to WHO by IARC scientists, there would be
905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

CA Labarrere, GS Kassab - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus
disease 19 (COVID-19) has numerous risk factors leading to severe disease with high …

The therapeutic potential of Kaemferol and other naturally occurring polyphenols might Be modulated by Nrf2-ARE Signaling pathway: current status and future …

Y Hussain, H Khan, KF Alsharif, A Hayat Khan… - Molecules, 2022 - mdpi.com
Kaempferol is a natural flavonoid, which has been widely investigated in the treatment of
cancer, cardiovascular diseases, metabolic complications, and neurological disorders. Nrf2 …

Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review

B Verro, C Saraniti, D Carlisi, C Chiesa-Estomba… - Cancers, 2023 - mdpi.com
Simple Summary Laryngeal squamous cell carcinoma is a prevalent cancer associated with
poor prognosis in advanced stages. Despite advancements in diagnostic tools (eg, narrow …

Bio-Waste Products of Mangifera indica L. Reduce Adipogenesis and Exert Antioxidant Effects on 3T3-L1 Cells

G Pratelli, D Carlisi, A D'Anneo, A Maggio, S Emanuele… - Antioxidants, 2022 - mdpi.com
Several studies highlighted the beneficial value of natural compounds in the prevention and
treatment of obesity. Here, we investigated the anti-obesity effects of extracts of peel and …

Hypertrophy and ER stress induced by palmitate are counteracted by mango peel and seed extracts in 3T3-L1 adipocytes

G Pratelli, D Di Liberto, D Carlisi, S Emanuele… - International Journal of …, 2023 - mdpi.com
A diet rich in saturated fatty acids (FAs) has been correlated with metabolic dysfunction and
ROS increase in the adipose tissue of obese subjects. Thus, reducing hypertrophy and …

Roles of NRF2 in fibrotic diseases: from mechanisms to therapeutic approaches

W Hao, M Li, Q Cai, S Wu, X Li, Q He, Y Hu - Frontiers in Physiology, 2022 - frontiersin.org
Fibrosis is a persistent inflammatory response that causes scarring and tissue sclerosis by
stimulating myofibroblasts to create significant quantities of extracellular matrix protein …

The oncobiome in gastroenteric and genitourinary cancers

DL D'Antonio, S Marchetti, P Pignatelli… - International Journal of …, 2022 - mdpi.com
Early evidence suggests a strong association of microorganisms with several human
cancers, and great efforts have been made to understand the pathophysiology underlying …