Redox signaling at the crossroads of human health and disease
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …
processes with biological activities. Redox homeostasis is a prerequisite for human health …
Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)
W Ke, KA Afonin - Advanced drug delivery reviews, 2021 - Elsevier
With recent advances in nanotechnology and therapeutic nucleic acids (TNAs), various
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …
Delivery of anti-miRNA for triple-negative breast cancer therapy using RNA nanoparticles targeting stem cell marker CD133
Triple-negative breast cancer (TNBC) is an aggressive disease with a short median time
from relapse to death. The increased aggressiveness, drug resistance, disease relapse, and …
from relapse to death. The increased aggressiveness, drug resistance, disease relapse, and …
Aptamers as modular components of therapeutic nucleic acid nanotechnology
M Panigaj, MB Johnson, W Ke, J McMillan… - Therapeutic RNA …, 2021 - taylorfrancis.com
Nucleic acids play a central role in all domains of life, either as genetic blueprints or as
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid …
regulators of various biochemical pathways. The 826chemical makeup of ribonucleic acid …
Opportunities, barriers, and a strategy for overcoming translational challenges to therapeutic nucleic acid nanotechnology
606Recent clinical successes using therapeutic nucleic acids (TNAs) have accelerated the
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
transition of nucleic acid nanotechnology toward therapeutic applications. Significant …
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation
KA Afonin, MA Dobrovolskaia, W Ke… - Advanced drug delivery …, 2022 - Elsevier
With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …
poised for clinical translation supported by several examples of FDA-approved nucleic acid …
3D RNA-scaffolded wireframe origami
Hybrid RNA: DNA origami, in which a long RNA scaffold strand folds into a target
nanostructure via thermal annealing with complementary DNA oligos, has only been …
nanostructure via thermal annealing with complementary DNA oligos, has only been …
Multivalent rubber-like RNA nanoparticles for targeted co-delivery of paclitaxel and MiRNA to silence the drug efflux transporter and liver cancer drug resistance
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. Analogous to the border customs, liver mainly functions as a filter to detoxify …
worldwide. Analogous to the border customs, liver mainly functions as a filter to detoxify …
Artificial Immune Cell, AI‐cell, a New Tool to Predict Interferon Production by Peripheral Blood Monocytes in Response to Nucleic Acid Nanoparticles
M Chandler, S Jain, J Halman, E Hong… - Small, 2022 - Wiley Online Library
Nucleic acid nanoparticles, or NANPs, rationally designed to communicate with the human
immune system, can offer innovative therapeutic strategies to overcome the limitations of …
immune system, can offer innovative therapeutic strategies to overcome the limitations of …
Expanding structural space for immunomodulatory nucleic acid nanoparticles via spatial arrangement of their therapeutic moieties
Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their
elongation with short oligonucleotides designed to self‐assemble into nucleic acid …
elongation with short oligonucleotides designed to self‐assemble into nucleic acid …