The protooncogene c-fos is rapidly activated after noxious stimuli to express the protein Fos
in spinal dorsal horn neurons that are in the 'correct'locations for nociceptive information …

Pain is normally mediated by nociceptive Aδ and C fibers, while Aβ fibers signal touch.
However, after nerve injury, Aβ fibers may signal pain. Using a genetic model, we tested the …

Spinal cord stimulation (SCS) treatment for chronic pain relies on the activation of primary
sensory fibres ascending to the brain in the dorsal columns. While the efficacy of SCS has …

The spinothalamic tract (STT) has been classically viewed as the major ascending pathway
for pain transmission while the dorsal column (DC) was thought to be involved primarily in …

Recent clinical and experimental studies have suggested that the dorsal column pathway
and specifically postsynaptic dorsal column neurons play an important role in the …

The place escape/avoidance paradigm (PEAP) is a behavioral test designed to quantify the
level of unpleasantness evoked by painful stimuli by assessing the willingness of a subject …

In this study, we examined characteristics of the neuropeptide Y–like immunoreactive (NPY-
LI) dorsal root ganglion (DRG) neurons after complete median nerve transection (CMNT) …

The dorsal column pathway consists of direct projections from primary afferents and of
ascending fibers of the post-synaptic dorsal column (PSDC) cells. This pathway mediates …

Electrical stimulation of the dorsal columns (DCs; spinal cord stimulation; SCS) has been
proposed to treat chronic neuropathic pain. SCS may activate a dual mechanism that would …

Background Allodynia and hyperalgesia present after surgical interventions are often a
major complain of surgical patients. It is thought that both peripheral and central …