Parkinson's disease (PD) is a progressive neurodegenerative disorder that currently has no
cure, but treatments are available to improve PD symptoms and maintain quality of life. In …

Serotonin (5-hydroxytryptamine, 5-HT) was identified initially as the active substance from
brain extracts that produced peripheral vasoconstriction (Rapport et al 1948). This …

Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two
seemingly distinct signaling systems that play regulatory roles in many neuronal functions …

Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons
in the central nervous system. However, the role of endogenous BDNF in the development …

The mechanism by which psychostimulants act as calming agents in humans with attention-
deficit hyperactivity disorder (ADHD) or hyperkinetic disorder is currently unknown. Mice …

Serotonin syndrome (SS) is an important drug-related complication of psychopharmacologic
therapy for major depression, bipolar affective disorder, obsessive-compulsive disorder …

Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons
in the adult brain and can prevent the severe loss of cortical 5-HT axons caused by the …

Background: Genetic variation of the promoter for the serotonin transporter (5-HTT) gene
has been associated with its functional capacity. In vitro, carriers of a short allele (s-carriers) …

Even though previous neuropsychological studies and clinical case reports have suggested
an association between pedophilia and frontocortical dysfunction, our knowledge about the …

Objective: Dysfunction of monoamine uptake mechanisms has been implicated in the
pathogenesis of alcohol dependence. The authors explored whether serotonergic …