Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

Cancer diagnostics and therapies have improved steadily over the last few decades,
markedly increasing life expectancy for patients at all ages. However, conventional and …

Cardiotoxicity is a significant complication of chemotherapeutic agents in cancer patients.
Cardiovascular incidents including LV dysfunction, heart failure (HF), severe arrhythmias …

PURPOSE To determine whether dexrazoxane provides effective cardioprotection during
frontline treatment of pediatric acute myeloid leukemia (AML) without increasing relapse risk …

A deeper understanding of the mechanisms of their cardiotoxicity reveals that there is no
'safe'dose of anthracyclines. However, certain risk factors, such as higher lifetime …

Background Cardiotoxicity is among the most important adverse effects of childhood cancer
treatment. Anthracyclines, mitoxantrone and radiotherapy involving the heart are its main …

Innovative therapeutic strategies in childhood cancer led to a significant reduction in cancer-
related mortality. Cancer survivors are a growing fragile population, at risk of long-term side …

Over the past few decades, the diagnosis and management of children with various
malignancies have improved tremendously. As a result, there are an increasing number of …

Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL) is an aggressive B-ALL
malignancy associated with high rates of relapse and inferior survival rate. While targeted …

Childhood cancer survival has improved significantly in the past few decades, reaching
rates of 80% or more at 5 years. However, with improved survival, early-and late-occurring …