Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

[HTML][HTML] PCOS and role of cumulus gene expression in assessing oocytes quality

N Sayutti, MA Abu, MF Ahmad - Frontiers in Endocrinology, 2022 - frontiersin.org
The global infertility rate has been declining from year to year. PCOS is one of the treatable
accountable causes contributing to anovulatory infertility. Nevertheless, the success rate of …

[HTML][HTML] Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

NEH Mimouni, I Paiva, AL Barbotin, FE Timzoura… - Cell metabolism, 2021 - cell.com
Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder
affecting women of reproductive age. PCOS has a strong heritable component, but its …

[HTML][HTML] Single-cell reconstruction of follicular remodeling in the human adult ovary

X Fan, M Bialecka, I Moustakas, E Lam… - Nature …, 2019 - nature.com
The ovary is perhaps the most dynamic organ in the human body, only rivaled by the uterus.
The molecular mechanisms that regulate follicular growth and regression, ensuring ovarian …

[HTML][HTML] Molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells

J Li, H Chen, M Gou, C Tian, H Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian
morphology, hyperandrogenism, ovulatory dysfunction, and infertility. Furthermore, PCOS …

Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral …

E Nilsson, R Klukovich, I Sadler-Riggleman, D Beck… - Epigenetics, 2018 - Taylor & Francis
Two of the most prevalent ovarian diseases affecting women's fertility and health are Primary
Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies …

[HTML][HTML] Autophagy is activated in the ovarian tissue of polycystic ovary syndrome

D Li, Y You, FF Bi, TN Zhang, J Jiao, TR Wang… - …, 2018 - rep.bioscientifica.com
The importance of autophagy in polycystic ovary syndrome (PCOS)-related metabolic
disorders is increasingly being recognized, but few studies have investigated the role of …

Transcriptomic integrity of human oocytes used in ARTs: technical and intrinsic factor effects

B Ducreux, C Patrat, J Trasler… - Human Reproduction …, 2024 - academic.oup.com
Background Millions of children have been born throughout the world thanks to ARTs, the
harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the …

[HTML][HTML] Single-cell transcriptomic analysis reveals mitochondrial dynamics in oocytes of patients with polycystic ovary syndrome

L Qi, B Liu, X Chen, Q Liu, W Li, B Lv, X Xu… - Frontiers in …, 2020 - frontiersin.org
Polycystic ovary syndrome (PCOS), characterized by polycystic ovarian morphology, ovarian
follicular maturation arrest, and hormonal disorders, affects numerous women in the …

miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1

T Wang, Y Liu, M Lv, Q Xing, Z Zhang, X He, Y Xu… - Gene, 2019 - Elsevier
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic heterogeneous disorder.
The incidence of which reaches 5% to 10% among reproductive-age women. Abnormal …