Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Coated pits assemble by growth of a clathrin lattice, which is linked by adaptors to the
underlying membrane. How does this process start? We used live-cell TIRF imaging with …

Numerous endocytic accessory proteins (EAPs) mediate assembly and maturation of
clathrin-coated pits (CCPs) into cargo-containing vesicles. Analysis of EAP function through …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

During development and tissue homeostasis, patterns of cellular organization, proliferation
and movement are highly choreographed. Receptor tyrosine kinases (RTKs) have a crucial …

Clathrin is considered the prototype vesicle coat protein whose self-assembly mediates
sorting of membrane cargo and recruitment of lipid modifiers. Detailed knowledge of clathrin …

Up to 60 different proteins are recruited to the site of clathrin-mediated endocytosis in an
ordered sequence. These accessory proteins have roles during all the different stages of …

Clathrin mediated endocytosis (CME) is the main route of receptor internalization in
mammalian cells and this well conserved mechanism has been intensively studied for over …

The epidermal growth factor (EGF) receptor (EGFR) controls many aspects of cell
physiology. EGF binding to EGFR elicits the membrane recruitment and activation of …