Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the
antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH …

There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Aging is defined as a progressive time‐related accumulation of changes responsible for or
at least involved in the increased susceptibility to disease and death. The brain seems to be …

Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being
detected peripherally as well as associated with the vulnerable regions of the brain affected …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks
of AD are amyloid plaques [aggregates of amyloid beta (A)] and neurofibrillary tangles …

Background Extant data from in vivo animal models and postmortem studies indicate that
Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant …

It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …