Spatial genomics: mapping human steatotic liver disease

KP Matchett, J Paris, SA Teichmann… - Nature Reviews …, 2024 - nature.com
Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-
alcoholic fatty liver disease) is a leading cause of chronic liver disease worldwide. MASLD …

Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencing

Q Xue, W Peng, S Zhang, X Wei, L Ye, Z Wang… - Frontiers in …, 2023 - frontiersin.org
Immunotherapy has made great strides in the treatment of lung cancer, but a significant
proportion of patients still do not respond to treatment. Therefore, the identification of novel …

Single‐cell RNA sequencing analysis reveals transcriptional heterogeneity of multiple primary lung cancer

W Guo, B Zhou, F Bie, Q Huai, X Xue… - Clinical and …, 2023 - Wiley Online Library
Introduction With the advancements in early diagnosis, more and more patients with multiple
primary lung cancer (MPLC) have been identified. However, the progression of MPLC …

Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil

H Peng, X Wu, S Liu, M He, C Tang… - Clinical and …, 2023 - Wiley Online Library
Background The cellular dynamics in the tumour microenvironment (TME) along with non‐
small cell lung cancer (NSCLC) progression remain unclear. Methods Multiplex …

Functional status and spatial architecture of tumor-infiltrating CD8+ T cells are associated with lymph node metastases in non-small cell lung cancer

G Yang, S Cai, M Hu, C Li, L Yang, W Zhang… - Journal of Translational …, 2023 - Springer
Abstract Background Anti-PD-(L) 1 immunotherapy has been recommended for non-small
cell lung cancer (NSCLC) patients with lymph node metastases (LNM). However, the exact …

Systemic inflammation influences the prognosis of patients with radically resected non‐small cell lung cancer and correlates with the immunosuppressive …

P Wang, S Wang, Z Sun, H Li, Y Zhao… - … Journal of Cancer, 2023 - Wiley Online Library
The impact of host condition on prognosis of non‐small cell lung cancer (NSCLC) and the
interaction between host and NSCLC remain unclear. This study investigated the …

Macrophage barrier in the tumor microenvironment and potential clinical applications

S Ji, Y Shi, B Yin - Cell Communication and Signaling, 2024 - Springer
The tumor microenvironment (TME) constitutes a complex microenvironment comprising a
diverse array of immune cells and stromal components. Within this intricate context, tumor …

Toolkit for mapping the clonal landscape of tumor-infiltrating B cells

EO Serebrovskaya, EA Bryushkova, DK Lukyanov… - Seminars in …, 2024 - Elsevier
Our current understanding of whether B cell involvement in the tumor microenvironment
benefits the patient or the tumor-in distinct cancers, subcohorts and individual patients-is …

FOXP3: A Player of Immunogenetic Architecture in Lung Cancer

I Ziółkowska-Suchanek, M Żurawek - Genes, 2024 - mdpi.com
The transcription factor forkhead box protein 3 (FOXP3) is considered to be a prominent
component of the immune system expressed in regulatory T cells (Tregs). Tregs are …

Examining the spatial distribution of tumor-infiltrating immune cells in patients with stage I to IIIA LUAD

W Du, F Yang, Z Hui, J Zhang, M Shen… - Journal of Leukocyte …, 2024 - academic.oup.com
This study aimed to examine the spatial distribution of immune cells by application of Gcross
function in 170 patients with stage I to IIIA lung adenocarcinoma (LUAD) and explore its …