Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM)
that is strongly associated with approximately five-fold increased risk of cardiovascular …

Cytokines and reactive oxygen species are inflammatory mediators that lead to increased
sensitivity to painful stimuli, and their inhibition represents a therapeutic approach in …

Pain is an unpleasant sensation associated with a wide range of injuries and diseases, and
affects approximately 20% of adults in the world. The discovery of new and more effective …

Background ATP-sensitive potassium (KATP) channels in neurons regulate excitability,
neurotransmitter release and mediate protection from cell-death. Furthermore, activation of …

The aim of this study was to examine if the peripheral antinociceptive effects of diclofenac
and indomethacin involve the sequential participation of NO and cGMP synthesis followed …

Resveratrol is an important phenolic phytochemical from the therapeutic perspective. It has
therapeutic impacts over wide range of diseases, especially the ones related to oxidative …

Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor and is predominantly used in the
treatment of erectile dysfunction. While maintaining an excellent safety and tolerability profile …

GPR35, previously an orphan G-protein coupled receptor, is a receptor for kynurenic acid.
Here we examine the distribution of GPR35 in the rat dorsal root ganglion (DRG) and the …

Phosphodiesterases (PDEs) are enzymes that break down the phosphodiesteric bond of the
cyclic nucleotides, cAMP and cGMP, second messengers that regulate many biological …