Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

The increasing threat of Pseudomonas aeruginosa high-risk clones

A Oliver, X Mulet, C López-Causapé, C Juan - Drug Resistance Updates, 2015 - Elsevier
The increasing prevalence of chronic and hospital-acquired infections produced by
multidrug-resistant (MDR) or extensively drug-resistant (XDR) Pseudomonas aeruginosa …

Epidemiology, biology, and impact of clonal Pseudomonas aeruginosa infections in cystic fibrosis

MD Parkins, R Somayaji, VJ Waters - Clinical microbiology …, 2018 - Am Soc Microbiol
Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …

[HTML][HTML] Microbial dysbiosis: rethinking disease in marine ecosystems

S Egan, M Gardiner - Frontiers in microbiology, 2016 - frontiersin.org
With growing environmental pressures placed on our marine habitats there is concern that
the prevalence and severity of diseases affecting marine organisms will increase. Yet …

[HTML][HTML] Recent advances in understanding Pseudomonas aeruginosa as a pathogen

J Klockgether, B Tümmler - F1000Research, 2017 - ncbi.nlm.nih.gov
The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen
causing acute and chronic infections in predisposed human subjects. Here we review recent …

[HTML][HTML] Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

M Ruffin, E Brochiero - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Epithelial tissues protecting organs from the environment are the first-line of defense against
pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain …

[HTML][HTML] Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

L Freschi, J Jeukens, I Kukavica-Ibrulj, B Boyle… - Frontiers in …, 2015 - frontiersin.org
The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes
and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic …

Insect pathogenicity in plant-beneficial pseudomonads: phylogenetic distribution and comparative genomics

P Flury, N Aellen, B Ruffner, M Péchy-Tarr… - The ISME …, 2016 - academic.oup.com
Bacteria of the genus Pseudomonas occupy diverse environments. The Pseudomonas
fluorescens group is particularly well-known for its plant-beneficial properties including …

The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages

EA Ozer, E Nnah, X Didelot, RJ Whitaker… - Genome biology and …, 2019 - academic.oup.com
The diversification of microbial populations may be driven by many factors including
adaptation to distinct ecological niches and barriers to recombination. We examined the …

[HTML][HTML] Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis

JA Bartell, AS Blazier, P Yen, JC Thøgersen… - Nature …, 2017 - nature.com
Virulence-linked pathways in opportunistic pathogens are putative therapeutic targets that
may be associated with less potential for resistance than targets in growth-essential …