Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

To achieve homeostasis, cells evolved dynamic and self-regulating quality control
processes to adapt to new environmental conditions and to prevent prolonged damage. We …

Macroautophagy/autophagy is a conserved transport pathway where targeted structures are
sequestered by phagophores, which mature into autophagosomes, and then delivered into …

Proton leakage from organelles is a common signal for noncanonical light chain 3B (LC3B)
lipidation and inflammasome activation, processes induced upon stimulator of interferon …

Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

The eukaryotic endomembrane system is a complex series of interconnected membranous
organelles that play important roles in responding to stress and maintaining cell …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

ATG8 family proteins are evolutionary conserved ubiquitin-like modifiers, which become
attached to the headgroup of the membrane lipid phosphatidylethanolamine in a process …