Background Eukaryotic cells demonstrate two tightly linked vesicular transport systems,
comprising intracellular vesicle transport and extracellular vesicle transport system …

The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage
disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate autophagic genes by …

Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic
enzymes. The detrimental consequences of lysosomal leakage have been well known since …

Cells harness multiple pathways to maintain lysosome integrity, a central homeostatic
process. Damaged lysosomes can be repaired or targeted for degradation by lysophagy, a …

LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy
machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5 …

Selective autophagy helps eukaryotes to cope with endogenous dangers or foreign
invaders; its initiation often involves membrane damage. By studying a Salmonella effector …

Autophagy is the primary catabolic program of the cell that promotes survival in response to
metabolic stress. It is tightly regulated by a suite of kinases responsive to nutrient status …

Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and
TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular …

The dynamics and coordination between autophagy machinery and selective receptors
during mitophagy are unknown. Also unknown is whether mitophagy depends on pre …

Although commonly associated with autophagosomes, LC3 can also be recruited to
membranes by covalent lipidation in a variety of non-canonical contexts. These include …