Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Vaccines are one of the most cost effective methods to control infectious diseases and at the
same time one of the most complex products of the pharmaceutical industry. In contrast to …

Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes
(T2D) and related mouse models. One dysmetabolic biochemical consequence is the non …

CD4+ helper T cells contribute important functions to the immune response during pathogen
infection and tumor formation by recognizing antigenic peptides presented by class II major …

T cells play a critical role in the adaptive immune response, recognizing peptide antigens
presented on the cell surface by major histocompatibility complex (MHC) proteins. While …

Compared with DR and DQ, knowledge of the binding repertoires and specificities of HLA-
DP alleles is somewhat limited. However, a growing body of literature has indicated the …

Several naturally occurring anti-insulin CD4 T cells were isolated from islet infiltrates of NOD
mice. In accordance with the results of others, these T cells recognized the segment of the β …

T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide
variety of antigenic peptides displayed in a given major histocompatibility complex (MHC) …

A crucial step in the immune response is the binding of antigenic peptides to major
histocompatibility complex (MHC) proteins. Class II MHC proteins present their bound …

Submonomer synthesis of aza-peptides featuring regioselective alkylation of peptide-bound
aza-Gly residues provided ten aza-analogues of the Growth Hormone Releasing Peptide-6 …