Despite significant advancements made in the treatment of cancer during the past several
decades, it remains one of the leading causes of death worldwide killing approximately 9.6 …

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face
the complex cancer biology, based on the combined use of different natural and synthetic …

Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million
people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several …

Hepatocellular carcinoma (HCC) is one of the most common cancers reported worldwide
with poor morbidity and high mortality rates. HCC is a very vascular solid tumour as …

Hepatocellular carcinoma (HCC) is one of the most common malignant diseases worldwide
and comes third in cancer-related mortality. Although there is a broad spectrum of treatment …

Hepatocellular carcinoma is the seventh most common type of cancer in the world, with
limited treatment options. A promising strategy to treat cancer is to associate …

Plant sterol (PS)(1 g/100 mL) enriched milk-based fruit beverages with or without
galactooligosaccharides (GOS)(1.8 g/100 mL) were used in differentiated Caco-2 cells …

In the present study, we report the synthesis, cytotoxicity determination and molecular
modeling studies of twelve novel indole-based hydrazone derivatives (IH1-IH12). To obtain …

Sorafenib, an oral multiple kinase inhibitor, is the standardized treatment for hepatocellular
carcinoma (HCC). One strategy to improve HCC therapy is to combine agents that target key …

Neonatal anoxia is linked to long‐lasting neurodevelopmental deficits. Due to the lack of
pharmacological intervention to treat neonatal anoxia, there is interest in finding new …