Alcohol-associated tissue injury: current views on pathophysiological mechanisms

L Simon, FM Souza-Smith… - Annual review of …, 2022 - annualreviews.org
At-risk alcohol use is a major contributor to the global health care burden and leads to
preventable deaths and diseases including alcohol addiction, alcoholic liver disease …

Transcriptional and epigenetic regulation of monocyte and macrophage dysfunction by chronic alcohol consumption

DC Malherbe, I Messaoudi - Frontiers in immunology, 2022 - frontiersin.org
Drinking alcohol, even in moderation, can affect the immune system. Studies have shown
disproportionate effects of alcohol on circulating and tissue-resident myeloid cells …

The impact of alcohol use disorder on tuberculosis: a review of the epidemiology and potential immunologic mechanisms

GW Wigger, TC Bouton, KR Jacobson… - Frontiers in …, 2022 - frontiersin.org
Globally, an estimated 107 million people have an alcohol use disorder (AUD) leading to 2.8
million premature deaths each year. Tuberculosis (TB) is one of the leading causes of death …

A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues

K Crotty, P Anton, LG Coleman… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Alcohol misuse contributes to the dysregulation of immune responses and multiorgan
dysfunction across various tissues, which are associated with higher risk of morbidity and …

Mitochondrial dysfunction: at the nexus between alcohol-associated immunometabolic dysregulation and tissue injury

RW Siggins, PM McTernan, L Simon… - International Journal of …, 2023 - mdpi.com
Alcohol misuse, directly or indirectly as a result of its metabolism, negatively impacts most
tissues, including four with critical roles in energy metabolism regulation: the liver, pancreas …

Polydatin attenuates chronic alcohol consumption-induced cardiomyopathy through a SIRT6-dependent mechanism

LM Yu, X Dong, N Li, H Jiang, JK Zhao, YL Xu… - Food & Function, 2022 - pubs.rsc.org
Polydatin has attracted much attention as a potential cardioprotective agent against
ischemic heart disease and diabetic cardiomyopathy. However, the effect and mechanism of …

Association between alcohol intake and arterial stiffness in healthy adults: a systematic review

R Del Giorno, A Maddalena, S Bassetti, L Gabutti - Nutrients, 2022 - mdpi.com
Background: Arterial stiffness as assessed by Pulse Wave Velocity (PWV) represents an
independent predictor of cardiovascular disease. Several dietary compounds and lifestyle …

Alcohol-induced glycolytic shift in alveolar macrophages is mediated by hypoxia-inducible factor-1 alpha

NL Morris, DN Michael, KM Crotty, SS Chang… - Frontiers in …, 2022 - frontiersin.org
Excessive alcohol use increases the risk of developing respiratory infections partially due to
impaired alveolar macrophage (AM) phagocytic capacity. Previously, we showed that …

Alcohol and immunology: mechanisms of multi-organ damage. Summary of the 2022 alcohol and immunology research interest group (AIRIG) meeting

RH McMahan, P Anton, LG Coleman, GAM Cresci… - Alcohol, 2023 - Elsevier
On October 26th, 2022 the annual Alcohol and Immunology Research Interest Group
(AIRIG) meeting was held as a satellite symposium at the annual meeting of the Society for …

[HTML][HTML] Vascular injury associated with ethanol intake is driven by AT1 receptor and mitochondrial dysfunction

WMC Awata, JV Alves, RM Costa… - Biomedicine & …, 2023 - Elsevier
Abstract Background Renin-angiotensin (Ang II)-aldosterone system (RAAS) is crucial for
the cardiovascular risk associated with excessive ethanol consumption. Disturbs in …