[HTML][HTML] Large language models improve annotation of viral proteins

ZN Flamholz, SJ Biller, L Kelly - Research square, 2023 - ncbi.nlm.nih.gov
Viral sequences are poorly annotated in environmental samples, a major roadblock to
understanding how viruses influence microbial community structure. Current annotation …

Development of carrageenan-immobilized lytic coliphage vB_Eco2571-YU1 hydrogel for topical delivery of bacteriophages in wound dressing applications

KB Narayanan, R Bhaskar, SM Choi, SS Han - International Journal of …, 2024 - Elsevier
Bacteriophages are employed as cost-effective and efficient antibacterial agents to counter
the emergence of antibiotic-resistant bacteria and other host bacteria in phage therapy. The …

Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus

J Yang, JZ Bowring, J Krusche, E Lehmann, BS Bejder… - Cell reports, 2023 - cell.com
Bacteria use quorum sensing (QS) to coordinate group behavior in response to cell density,
and some bacterial viruses (phages) also respond to QS. In Staphylococcus aureus, the agr …

Isolation and identification of the broad-spectrum high-efficiency phage vB_SalP_LDW16 and its therapeutic application in chickens

S Cao, W Yang, X Zhu, C Liu, J Lu, Z Si, L Pei… - BMC veterinary …, 2022 - Springer
Background Salmonella infection in livestock and poultry causes salmonellosis, and is
mainly treated using antibiotics. However, the misuse use of antibiotics often triggers the …

[HTML][HTML] Anti-CRISPR proteins as a therapeutic agent against drug-resistant bacteria

P Vyas - Microbiological research, 2022 - Elsevier
The continuous deployment of various antibiotics to treat multiple serious bacterial infections
leads to multidrug resistance among the bacterial population. It has failed the standard …

Novel lytic phages protect cells and mice against Pseudomonas aeruginosa infection

F Chen, X Cheng, J Li, X Yuan, X Huang… - Journal of …, 2021 - Am Soc Microbiol
With the fast emergence of serious antibiotic resistance and the lagging discovery of novel
antibacterial drugs, phage therapy for pathogenic bacterial infections has acquired great …

Two novel phages PSPa and APPa inhibit planktonic, sessile and persister populations of Pseudomonas aeruginosa, and mitigate its virulence in Zebrafish model

C Karthika, N Malligarjunan, R Jothi, T Kasthuri… - Scientific Reports, 2023 - nature.com
The present study explores the avenue of phage therapy as an alternative antimicrobial
therapeutic approach to counter multidrug-resistant (MDR) Pseudomonas aeruginosa …

[PDF][PDF] Genomic characterization of four novel bacteriophages infecting the clinical pathogen Klebsiella pneumoniae

B Estrada Bonilla, AR Costa, DF Van Den Berg… - DNA …, 2021 - academic.oup.com
Bacteriophages are an invaluable source of novel genetic diversity. Sequencing of phage
genomes can reveal new proteins with potential uses as biotechnological and medical tools …

A review on mycobacteriophages: from classification to applications

S Hosseiniporgham, LA Sechi - Pathogens, 2022 - mdpi.com
Mycobacterial infections are a group of life-threatening conditions triggered by fast-or slow-
growing mycobacteria. Some mycobacteria, such as Mycobacterium tuberculosis, promote …

RNA and single-stranded DNA phages: unveiling the promise from the underexplored world of viruses

HM Nguyen, S Watanabe, S Sharmin… - International Journal of …, 2023 - mdpi.com
RNA and single-stranded DNA (ssDNA) phages make up an understudied subset of
bacteriophages that have been rapidly expanding in the last decade thanks to …