RNA structural dynamics as captured by molecular simulations: a comprehensive overview
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
Ribosome-inactivating proteins: Potent poisons and molecular tools
MJ Walsh, JE Dodd, GM Hautbergue - Virulence, 2013 - Taylor & Francis
Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been
shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of …
shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of …
[HTML][HTML] The fungal ribonuclease-like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA
HG Pennington, R Jones, S Kwon, G Bonciani… - PLoS …, 2019 - journals.plos.org
The biotrophic fungal pathogen Blumeria graminis causes the powdery mildew disease of
cereals and grasses. We present the first crystal structure of a B. graminis effector of …
cereals and grasses. We present the first crystal structure of a B. graminis effector of …
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
B Everts, L Hussaarts, NN Driessen… - Journal of Experimental …, 2012 - rupress.org
Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs
and abundantly present in soluble egg antigen, has recently been shown to condition …
and abundantly present in soluble egg antigen, has recently been shown to condition …
[HTML][HTML] HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus
M Schrettl, N Beckmann, J Varga, T Heinekamp… - PLoS …, 2010 - journals.plos.org
Iron is essential for a wide range of cellular processes. Here we show that the bZIP-type
regulator HapX is indispensable for the transcriptional remodeling required for adaption to …
regulator HapX is indispensable for the transcriptional remodeling required for adaption to …
SreA‐mediated iron regulation in Aspergillus fumigatus
M Schrettl, HS Kim, M Eisendle, C Kragl… - Molecular …, 2008 - Wiley Online Library
Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two
high‐affinity iron uptake systems: iron uptake mediated by the extracellular siderophore …
high‐affinity iron uptake systems: iron uptake mediated by the extracellular siderophore …
Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems
The deaminase-like fold includes, in addition to nucleic acid/nucleotide deaminases, several
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …
[HTML][HTML] Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans
Background Phytophthora infestans is the most devastating pathogen of potato and a model
organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host …
organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host …
[HTML][HTML] VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA
The highly persistent and often lethal human pathogen, Mycobacterium tuberculosis
contains at least 88 toxin–antitoxin genes. More than half of these encode VapC PIN domain …
contains at least 88 toxin–antitoxin genes. More than half of these encode VapC PIN domain …
[HTML][HTML] Characterization of Aspergillus fumigatus extracellular vesicles and their effects on macrophages and neutrophils functions
JAM Souza, LM Baltazar, VM Carregal… - Frontiers in …, 2019 - frontiersin.org
Extracellular vesicles (EVs) has been considered an alternative process for intercellular
communication. EVs release by filamentous fungi and the role of vesicular secretion during …
communication. EVs release by filamentous fungi and the role of vesicular secretion during …