RNA structural dynamics as captured by molecular simulations: a comprehensive overview

J Sponer, G Bussi, M Krepl, P Banáš, S Bottaro… - Chemical …, 2018 - ACS Publications
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Ribosome-inactivating proteins: Potent poisons and molecular tools

MJ Walsh, JE Dodd, GM Hautbergue - Virulence, 2013 - Taylor & Francis
Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been
shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of …

[HTML][HTML] The fungal ribonuclease-like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA

HG Pennington, R Jones, S Kwon, G Bonciani… - PLoS …, 2019 - journals.plos.org
The biotrophic fungal pathogen Blumeria graminis causes the powdery mildew disease of
cereals and grasses. We present the first crystal structure of a B. graminis effector of …

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

B Everts, L Hussaarts, NN Driessen… - Journal of Experimental …, 2012 - rupress.org
Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs
and abundantly present in soluble egg antigen, has recently been shown to condition …

[HTML][HTML] HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

M Schrettl, N Beckmann, J Varga, T Heinekamp… - PLoS …, 2010 - journals.plos.org
Iron is essential for a wide range of cellular processes. Here we show that the bZIP-type
regulator HapX is indispensable for the transcriptional remodeling required for adaption to …

SreA‐mediated iron regulation in Aspergillus fumigatus

M Schrettl, HS Kim, M Eisendle, C Kragl… - Molecular …, 2008 - Wiley Online Library
Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two
high‐affinity iron uptake systems: iron uptake mediated by the extracellular siderophore …

Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems

LM Iyer, D Zhang, IB Rogozin… - Nucleic acids research, 2011 - academic.oup.com
The deaminase-like fold includes, in addition to nucleic acid/nucleotide deaminases, several
catalytic domains such as the JAB domain, and others involved in nucleotide and ADP …

[HTML][HTML] Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans

S Raffaele, J Win, LM Cano, S Kamoun - BMC genomics, 2010 - Springer
Background Phytophthora infestans is the most devastating pathogen of potato and a model
organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host …

[HTML][HTML] VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

KS Winther, DE Brodersen, AK Brown… - Nature …, 2013 - nature.com
The highly persistent and often lethal human pathogen, Mycobacterium tuberculosis
contains at least 88 toxin–antitoxin genes. More than half of these encode VapC PIN domain …

[HTML][HTML] Characterization of Aspergillus fumigatus extracellular vesicles and their effects on macrophages and neutrophils functions

JAM Souza, LM Baltazar, VM Carregal… - Frontiers in …, 2019 - frontiersin.org
Extracellular vesicles (EVs) has been considered an alternative process for intercellular
communication. EVs release by filamentous fungi and the role of vesicular secretion during …