[HTML][HTML] Permeability of the endothelial barrier: identifying and reconciling controversies

L Claesson-Welsh, E Dejana, DM McDonald - Trends in molecular …, 2021 - cell.com
Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

[HTML][HTML] Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

R Hashimoto, J Takahashi, K Shirakura, R Funatsu… - Science …, 2022 - science.org
In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial cells and then transfers …

Nanoparticles' interactions with vasculature in diseases

JK Tee, LX Yip, ES Tan, S Santitewagun… - Chemical Society …, 2019 - pubs.rsc.org
The ever-growing use of inorganic nanoparticles (NPs) in biomedicine provides an exciting
approach to develop novel imaging and drug delivery systems, owing to the ease with which …

[HTML][HTML] The blood-brain barrier in Alzheimer's disease

E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …

Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31)

P Lertkiatmongkol, D Liao, H Mei, Y Hu… - Current opinion in …, 2016 - journals.lww.com
Owing to the unique ability of antibodies that bind the membrane proximal region of the
extracellular domain to trigger conformational changes leading to affinity modulation and …

[HTML][HTML] Reactive oxygen species in inflammation and tissue injury

SM Rizwan, P ReddySekhar… - Antioxidants & redox …, 2014 - liebertpub.com
Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Vascular contributions to Alzheimer's disease

LB Eisenmenger, A Peret, BM Famakin, A Spahic… - Translational …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Hypoxia‐inducible factor‐1 in physiological and pathophysiological angiogenesis: applications and therapies

A Zimna, M Kurpisz - BioMed research international, 2015 - Wiley Online Library
The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

[HTML][HTML] Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …